Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts
نویسندگان
چکیده
منابع مشابه
Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts
Neointimal hyperplasia is amongst the major causes of failure of bypass grafts. The disease progression varies from patient to patient due to a range of different factors. In this paper, a mathematical model will be used to understand neointimal hyperplasia in individual patients, combining information from biological experiments and patient-specific data to analyze some aspects of the disease,...
متن کاملRole of osteopontin in the development of neointimal hyperplasia in vein grafts.
OBJECTIVES Neointimal hyperplasia and superimposed atherosclerosis are central to late vein graft failure following coronary artery bypass grafting. Recent studies on post-injury arterial vessels have suggested a role of osteopontin (OPN) in the process of vascular remodelling. This study was designed to assess the in vivo performance of OPN following vein grafting. METHODS Bilateral saphenou...
متن کاملRetraction: Rapamycin-loaded nanoparticles for inhibition of neointimal hyperplasia in experimental vein grafts
Submit your manuscript at www.biomedcentral.com/submit * Correspondence: [email protected] Division of Vascular Surgery, Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjng, Jiangsu province, China Full list of author information is available at the end of the article Zou et al. Journal of Cardiothoracic Surgery 2012, 7:17 http://www.cardiothoracic...
متن کاملRapamycin-loaded nanoparticles for inhibition of neointimal hyperplasia in experimental vein grafts
BACKGROUND Nanoparticles (NPs) possess several advantages as a carrier system for intracellular delivery of therapeutic agents. Rapamycin is an immunosuppressive agent which also exhibits marked antiproliferative properties. We investigated whether rapamycin-loaded NPs can reduce neointima formation of vein graft disease in a rat model. METHODS Poly(lactic-co-glycolic acid) (PLGA) NPs-contain...
متن کاملPerivascular application of C-type natriuretic peptide attenuates neointimal hyperplasia in experimental vein grafts.
OBJECTIVE C-type natriuretic peptide (CNP), which is produced by vascular endothelial cells, exhibits anti-proliferative and anti-inflammatory effects. Cytotoxic T-lymphocytes may be involved in vein graft disease. Attenuation of vein graft disease necessitates a remodelling of the arterialized vein towards a more contractile phenotype which is characterized, among other factors, by the calponi...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2017
ISSN: 1664-042X
DOI: 10.3389/fphys.2017.00226